Vitamina A o Axeroftolo o Retinolo
Pubblicato il 04/06/2015
Si utilizza quale componente del composto vitaminico dei retinoidi del Metodo Di Bella (MDB). In questo composto rientra nella proporzione di 0,5 g per 1000 g di soluzione. Va assunta al mattino a digiuno almeno 15 minuti prima del pasto, facendo questo calcolo rispetto al peso corporeo: un adulto di 70 Kg può assumere circa 7 cc di soluzione di retinoidi contente la vitamina A. La determinazione può essere effettuata con una comune siringa da 10 cc, versando il contenuto in un cucchiaio. Piccole variazioni non hanno alcun carattere di tossicità per la composizione del preparato e la natura delle sostanze componenti.
Rientra nel gruppo dei retinoidi (link al documento di tipo scientifico “retinoidi”). E’ una vitamina liposolubile con formula C20 H28 componente del composto dei retinoidi MDB nella proporzione di 0,5 g per ogni litro di composto vitaminico i cui componenti oltre alla vitamina A sono: betacarotene 2g x 1000, acido trans retinoico 0,5 x 1000 e vitamina E 1000 g. E’ importante per le sue proprietà di prevenzione sia dei tumori che delle infezioni batteriche o virali e per la sua riconosciuta capacità d’attivare le difese immunitarie dell’organismo. La letteratura medica internazionale ha già riconosciuto questi effetti su tutti i tessuti epiteliali che costituiscono una parte vitale ed estesa del nostro organismo. Essi comprendono: le vie respiratorie, digestive, urogenitali, ghiandolari esocrine e i tessuti tegumentali come la pelle e gli annessi. Su tutti questi substrati la vitamina A agisce in maniera determinante e documentata preservandone integrità efficienza e funzionalità e promuovendo meccanismi di crescita controllati. Altro elemento fondamentale è la capacità della vitamina A e dei retinoidi d’impedire o comunque rallentare la trasformazione di una cellula normale in neoplastica, di ridifferenziarla, cioè riportarla alla normalità, se è iniziato il processo neoplastico, d’inibire la crescita delle cellule tumorali, la loro diffusione e favorire la loro morte naturale (apoptosi) con un meccanismo simile al ricambio cellulare. Pertanto l’attività antitumorale della A si estende dalla prevenzione alla terapia con meccanismi molteplici, complessi e documentati.
Solo ricerca in vitro (organi isolati, tessuti, cellule o sistemi biochimici - definizione del libro d'oro IUPAC)
- 1967 Aug: The Enzymatic Conversion of All-trans β-Carotene into Retinal;
- 1977 Nov: Differential binding to soluble nuclear receptors and effects on cell viability of retinol and retinoic acid in cultured retinoblastoma cells;
- 1978 Oct: The induction of differentiation in teratocarcinoma stem cells by retinoic acid;
- 1980 Mar: Binding of retinoids to human breast cancer cell lines and their effects on cell growth;
- 1982 Nov: Sensitivity of cultured human osteosarcoma and chondrosarcoma cells to retinoic acid;
- 1983 Feb: Induction of differentiation of human acute non-lymphocytic leukemia cells in primary culture by inducers of differentiation of human myeloid leukemia cell line HL-60;
- 1983 Oct: Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines;
- 1984 Jul: Retinoic acid stimulates 1,25-dihydroxyvitamin D3 binding in rat osteosarcoma cells;
- 1985 Jan-Feb: Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma;
- 1986 May: Differential Regulation by Retinoic Acid and Calcium of Transglutaminases in Cultured Neoplastic and Normal Human Keratinocytes;
- 1987 Aug: Differential effects of retinoic acid on the in vitro growth and cell-surface glycoconjugates of 2 human head and neck squamous-cell carcinomas;
- 1988 Jun: Effects of type beta transforming growth factor in combination with retinoic acid or tumor necrosis factor on proliferation of a human glioblastoma cell line and clonogenic cells from freshly resected human brain tumors;
- 1988 Sep: Terminal differentiation and growth inhibition of a rat rhabdomyosarcoma cell line (BA-HAN-1C) in vitro after exposure to retinoic acid;
- 1989 Jan: Inhibition of Moloney murine lymphoma and sarcoma growth in vivo by dietary retinoids;
- 1989 Feb: Modulation of growth and epidermal growth factor receptor activity by retinoic acid in human glioma cells;
- 1989 May: Modification of radiosensitivity and recovery from X ray damage in vitro by retinoic acid;
- 1989 Jul: Retinoic acid enhances VIP receptor expression and responsiveness in human neuroblastoma cell, SH-SY5Y;
- 1989 Nov: Modulation of growth, differentiation and glycoprotein synthesis by beta-all-trans retinoic acid in a multicellular tumor spheroid model for squamous carcinoma of the head and neck;
- 1990 Jan: Inhibition of growth and squamous-cell differentiation markers in cultured human head and neck squamous carcinoma cells by beta-all-trans retinoic acid;
- 1990 Apr: Retinoic acid inhibition of human breast carcinoma proliferation is accompanied by inhibition of the synthesis of a Mr 39,000 protein;
- 1991 Jul: Effect of retinoids and carotenoids on prostaglandin formation by oral squamous carcinoma cells;
- 1991 Jul: Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cells;
- 1991 Dec: RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements;
- 1992 Apr: The selective cytotoxic effect of carotenoids and alpha-tocopherol on human cancer cell lines in vitro;
- 1992 Aug: beta-Carotene and alpha-tocopherol are synergistic antioxidants;
- 1992 Oct: The effects of retinoic acid on the in vitro and in vivo growth of neuroblastoma cells;
- 1993 Feb: Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells;
- 1993 May: Effect of retinoic acid on the proliferation and secretory activity of androgen-responsive prostatic carcinoma cells;
- 1993 Nov: Inhibition of tumor cell-induced angiogenesis by retinoids, 1,25-dihydroxyvitamin D3 and their combination;
- 1994 Mar: Antiestrogenic effects of all-trans-retinoic acid and 1,25-dihydroxyvitamin D3 in breast cancer cells occur at the estrogen response element level but through different molecular mechanisms;
- 1994 Jun: Effects of retinoic acid metabolites on proliferation and differentiation of the clonal rhabdomyosarcoma cell line BA-HAN-1C;
- 1994 Jun: Modification of the effect of tamoxifen, cis-platin, DTIC, and interferon-alpha 2b on human melanoma cells in culture by a mixture of vitamins;
- 1994 Jul: Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues;
- 1994 Oct: Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines;
- 1995 Jun: Growth inhibition and apoptosis of RL human B lymphoma cells by vitamin E succinate and retinoic acid: role for transforming growth factor beta;
- 1995 Jun: Induction of transforming growth factor beta 1 and its receptors during all-trans-retinoic acid (RA) treatment of RA-responsive human neuroblastoma cell lines;
- 1995 Jul: Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice;
- 1995 Aug: Retinoic acid receptors and retinoid binding proteins in endometrial adenocarcinoma: differential expression of cellular retinoid binding proteins in endometrioid tumours;
- 1995 Sep: Effects of vitamin D and retinoic acid on human glioblastoma cell lines;
- 1996 Jan: Effect of individual and multiple antioxidant vitamins on growth and morphology of human nontumorigenic and tumorigenic parotid acinar cells in culture;
- 1996 Mar: All-trans-retinoic acid inhibits growth of human pancreatic cancer cell lines;
- 1996 Mar: Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells;
- 1996 May: Upregulation of cytokeratins 8 and 18 in human breast cancer T47D cells is retinoid-specific and retinoic acid receptor-dependent;
- 1996 Jun: Growth-inhibitory effects of vitamin D analogues and retinoids on human pancreatic cancer cells;
- 1996 Jul: Retinoic acid induces cells cultured from oral squamous cell carcinomas to become anti-angiogenic;
- 1996 Sep: Expression of the retinoic acid receptors (RARs) and retinoid X receptor (RXRs) genes in breast cancer;
- 1996 Sep: Retinoic acid nuclear receptor alpha(RAR alpha) plays a major role in retinoid-mediated inhibition of growth in human breast carcinoma cells;
- 1997 Jan: Ascorbic acid and beta-carotene as modulators of oxidative damage;
- 1997 Feb: Elevated expression of retinoic acid receptor-alpha (RAR alpha) in estrogen-receptor-positive breast carcinomas as detected by immunohistochemistry;
- 1997 Feb: In vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma;
- 1997 Mar: Effects of all-trans-retinoic acid and 13-cis-retinoic acid on breast-cancer cell lines: growth inhibition and apoptosis induction;
- 1997 Apr: 1,25-dihydroxyvitamin D3 and 9-cis-retinoic acid act synergistically to inhibit the growth of LNCaP prostate cells and cause accumulation of cells in G1;
- 1997 Jun: Synergistic antitumor effects of a combination of interferons and retinoic acid on human tumor cells in vitro and in vivo;
- 1997 Jul: Effects of retinoid X receptor-selective ligands on proliferation of prostate cancer cells;
- 1997 Oct: Activation of three distinct RXR/RAR heterodimers induces growth arrest and differentiation of neuroblastoma cells;
- 1997 Oct: Retinoid-mediated inhibition of cell growth with stimulation of apoptosis in aggressive B-cell lymphomas;
- 1997 Nov: all-trans retinoic acid enhances cisplatin-induced apoptosis in human ovarian adenocarcinoma and in squamous head and neck cancer cells;
- 1997 Nov: Analysis of retinoic acid receptor beta expression in normal and malignant laryngeal mucosa by a sensitive and routine applicable reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay method;
- 1997 Nov: Expression of retinoic acid receptor-beta 2 mRNA in normal cervical epithelium and cervical squamous cell carcinoma;
- 1997 Nov: Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids;
- 1997 Nov: Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation;
- 1998 Jan: All-trans retinoic acid (ATRA)-induced apoptosis is preceded by G1 arrest in human MCF-7 breast cancer cells;
- 1998 Jan: All-trans-retinoic acid metabolites significantly inhibit the proliferation of MCF-7 human breast cancer cells in vitro;
- 1998 Jun: A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells;
- 1998 Jul: Antiproliferative effect of carotenoids on human colon cancer cells without conversion to retinoic acid;
- 1998 Aug: Combinational effects of vitamin D3 and retinoic acid (all trans and 9 cis) on proliferation, differentiation, and programmed cell death in two small cell lung carcinoma cell lines;
- 1998 Oct: Beta-carotene with vitamins E and C offers synergistic cell protection against NOx;
- 1998 Oct: Inhibition of cancer cell growth by all-trans retinoic acid and its analog N-(4-hydroxyphenyl) retinamide: a possible mechanism of action via regulation of retinoid receptors expression;
- 1998 Oct: Reduced expression of retinoic acid receptor beta protein (RAR beta) in human papillary thyroid carcinoma: immunohistochemical and western blot study;
- 1998 Nov: Retinoic acid down-regulates the expression of the vasoactive intestinal polypeptide receptor type-1 in human breast carcinoma cell lines;
- 1998 Dec: Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans retinoic acid;
- 1998 Dec: Retinoic acid and interferon alpha act synergistically as antiangiogenic and antitumor agents against human head and neck squamous cell carcinoma;
- 1999 Apr: 1,25-Dihydroxyvitamin D3 induces differentiation of a retinoic acid-resistant acute promyelocytic leukemia cell line (UF-1) associated with expression of p21(WAF1/CIP1) and p27(KIP1);
- 1999 Jun: Effects of vitamin D and retinoids on the differentiation and growth in vitro of canine osteosarcoma and its clonal cell lines;
- 1999 Jun: Expression of retinoid receptor genes and proteins in non-small-cell lung cancer;
- 1999 Jul: Induction of retinoic acid receptor beta mediates growth inhibition in retinoid resistant human colon carcinoma cells;
- 1999 Jul: Overexpression of retinoic acid receptor beta in head and neck squamous cell carcinoma cells increases their sensitivity to retinoid-induced suppression of squamous differentiation by retinoids;
- 1999 Aug: Novel 20-epi-vitamin D3 analog combined with 9-cis-retinoic acid markedly inhibits colony growth of prostate cancer cells;
- 1999 Nov: Involvement of nuclear steroid/thyroid/retinoid receptors and of protein kinases in the regulation of growth and of c-erbB and retinoic acid receptor expression in MCF-7 breast cancer cells;
- 2000 Mar: Influence of vitamin D and retinoids on the induction of functional differentiation in vitro of canine osteosarcoma clonal cells;
- 2000 Apr: 1,25-Dihydroxyvitamin D3 and all-trans-retinoic acid sensitize breast cancer cells to chemotherapy-induced cell death;
- 2000 Apr: All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells;
- 2000 Apr: Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells;
- 2000 May: Differentiation, proliferation and adhesion of human neuroblastoma cells after treatment with retinoic acid;
- 2000 Jun: Bcl-2 accelerates retinoic acid-induced growth arrest and recovery in human gastric cancer cells;
- 2000 Jun: Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition;
- 2000 Jul: Differential and antagonistic effects of 9-cis-retinoic acid and vitamin D analogues on pancreatic cancer cells in vitro;
- 2000 Sep: Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade;
- 2000 Oct: Activation of retinoic acid receptor alpha is sufficient for full induction of retinoid responses in SK-BR-3 and T47D human breast cancer cells;
- 2000 Dec: Upregulation of gap junctional intercellular communication and connexin 43 expression by cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells;
- 2001 Jan: Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer;
- 2001 Jan: Detection of the retinoic acid-regulated genes in a RTBM1 neuroblastoma cell line using cDNA microarray;
- 2001 Jan: Retinoic acid-induced apoptosis of the CHP134 neuroblastoma cell line is associated with nuclear accumulation of p53 and is rescued by the GDNF/Ret signal;
- 2001 Feb: Retinoic acid dramatically enhances the arsenic trioxide-induced cell cycle arrest and apoptosis in retinoic acid receptor alpha-positive human T-cell lymphotropic virus type-I-transformed cells;
- 2001 Mar: Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma;
- 2001 May: 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects;
- 2001 Jun: Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid;
- 2001 Jun: Expression of retinoic acid receptor gamma correlates with retinoic acid sensitivity and metabolism in head and neck squamous cell carcinoma cell lines;
- 2001 Jun: Synergistic anti-proliferative effects of vitamin D derivatives and 9-cis retinoic acid in SH-SY5Y human neuroblastoma cells;
- 2001 Apr: Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma;
- 2001 Aug: Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines;
- 2002 Jan: Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells;
- 2002 Jan-Feb: Analysis of vitamin D-receptor (VDR) and retinoid X-receptor alpha in breast cancer;
- 2002 Mar: The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil;
- 2002 May: Degradation of RXRs influences sensitivity of rat osteosarcoma cells to the antiproliferative effects of calcitriol;
- 2002 Jul: High levels of cellular retinol binding protein-1 expression in leiomyosarcoma: possible implications for diagnostic evaluation;
- 2002 Jul: Retinoic acid modulates the ability of macrophages to participate in the induction of the angiogenic phenotype in head and neck squamous cell carcinoma;
- 2002 Sep: Effects of retinoic acid on metastasis and its related proteins in gastric cancer cells in vivo and in vitro;
- 2002 Sep: Suppression of growth by all-trans retinoic acid requires prolonged induction of interferon regulatory factor 1 in cervical squamous carcinoma (SiHa) cells;
- 2003 Mar: Early vitronectin receptor downregulation in a melanoma cell line during all-trans retinoic acid-induced apoptosis;
- 2003 Apr: The synthetic retinoid RO 13-6307 induces neuroblastoma differentiation in vitro and inhibits neuroblastoma tumour growth in vivo;
- 2003 Jul: Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone;
- 2003 Aug: Combination treatment with 1alpha,25-dihydroxyvitamin D3 and 9-cis-retinoic acid directly inhibits human telomerase reverse transcriptase transcription in prostate cancer cells;
- 2003 Aug: Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid;
- 2003 Sep: All-trans-retinoic acid-induced apoptosis in human medulloblastoma: activation of caspase-3/poly(ADP-ribose) polymerase 1 pathway;
- 2003 Oct: Inhibition of tumor growth by biodegradable microspheres containing all-trans-retinoic acid in a human head-and-neck cancer xenograft;
- 2003 Nov: Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase;
- 2003 Dec: Anti-tumor effect of vitamin A and D on head and neck squamous cell carcinoma;
- 2004 Jan: All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells;
- 2004 Feb: Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells;
- 2004 Mar: Differential expression of retinoic acid receptor beta (RARbeta) and the AP-1 transcription factor in normal, premalignant and malignant human laryngeal tissues;
- 2004 Mar-Apr: All-trans retinoic acid (ATRA) suppresses transcription of human papillomavirus type 16 (HPV16) in a dose-dependent manner;
- 2004 Jul: A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands;
- 2004 Jul: All-trans retinoic acid-responsive genes identified in the human SH-SY5Y neuroblastoma cell line and their regulated expression in the nervous system of early embryos;
- 2004 Jul: Growth and EGFR regulation in breast cancer cells by vitamin D and retinoid compounds;
- 2004 Aug: Aberrant cellular retinol binding protein 1 (CRBP1) gene expression and promoter methylation in prostate cancer;
- 2004 Nov: All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5;
- 2004 Dec: Retinoids arrest breast cancer cell proliferation: retinoic acid selectively reduces the duration of receptor tyrosine kinase signaling;
- 2005 Jan: Retinoic acid inhibits the proliferative response induced by CD40 activation and interleukin-4 in mantle cell lymphoma;
- 2005 Jun: A novel retinoid-related molecule inhibits pancreatic cancer cell proliferation by a retinoid receptor independent mechanism via suppression of cell cycle regulatory protein function and induction of caspase-associated apoptosis;
- 2005 Aug: beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation;
- 2005 Sep: Retinoid receptors in ovarian cancer: expression and prognosis;
- 2005 Oct: Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells;
- 2006 Feb: Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice;
- 2006 Mar: Clinical significance of altered expression of retinoid receptors in oral precancerous and cancerous lesions: relationship with cell cycle regulators;
- 2006 Jun: Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid;
- 2006 Jun: Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis;
- 2006 Jul: Retinoic acid and ascorbic acid act synergistically in inhibiting human breast cancer cell proliferation;
- 2007 Jan: Suppression of mammary carcinoma cell growth by retinoic acid: the cell cycle control gene Btg2 is a direct target for retinoic acid receptor signaling;
- 2007 Feb: Effects of all-trans-retinoic on human gastric cancer cells BGC-823;
- 2007 Sep: Combinational treatment with retinoic acid derivatives in non-small cell lung carcinoma in vitro;
- 2007 Oct: Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function;
- 2007 Nov: Combination of all-trans retinoic acid and taxol regressed glioblastoma T98G xenografts in nude mice;
- 2007 Dec: Combination of all-trans retinoic acid and interferon-gamma suppressed PI3K/Akt survival pathway in glioblastoma T98G cells whereas NF-kappaB survival signaling in glioblastoma U87MG cells for induction of apoptosis;
- 2008 Mar: Retinoids induced astrocytic differentiation with down regulation of telomerase activity and enhanced sensitivity to taxol for apoptosis in human glioblastoma T98G and U87MG cells;
- 2008 Apr: All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB;
- 2008 Jun: Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma;
- 2008 Jun: Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells;
- 2008 Aug: Combination of all-trans retinoic acid and interferon-gamma upregulated p27(kip1) and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells;
- 2008 Oct: Effect of all-trans-retinoic acid on C6 glioma cell proliferation and differentiation;
- 2008 Oct: Global analysis of gene expression changes during retinoic acid-induced growth arrest and differentiation of melanoma: comparison to differentially expressed genes in melanocytes vs melanoma;
- 2009 Feb: Beta-carotene degradation products - formation, toxicity and prevention of toxicity;
- 2009 Feb: Chmp 1A is a mediator of the anti-proliferative effects of all-trans retinoic acid in human pancreatic cancer cells;
- 2009 Feb: Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells;
- 2009 Feb: The role of Cdk5 in retinoic acid-induced apoptosis of cervical cancer cell line;
- 2009 Mar: Retinoic acid regulates Fas-induced apoptosis in Jurkat T cells: reversal of mitogen-mediated repression of Fas DISC assembly;
- 2009 Apr: ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome;
- 2009 May: Enhancement of 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced HL-60 leukemia cell differentiation by Panax ginseng;
- 2009 May: Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion;
- 2009 Jun: Genomic antagonism between retinoic acid and estrogen signaling in breast cancer;
- 2009 Jul: A unique cytoplasmic localization of retinoic acid receptor-gamma and its regulations;
- 2009 Sep: Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells;
- 2009 Sep: Inhibition of all-trans retinoic acid-induced granulocytic differentiation of WEHI-3B D+ cells by forced expression of SCL (TAL1) and GATA-1;
- 2009 Sep: Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines;
- 2009 Oct: Retinoid signaling regulates breast cancer stem cell differentiation;
- 2009 Nov: Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells;
- 2009 Nov: Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells;
- 2009 Nov: UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid;
- 2010 Jan: Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer;
- 2010 Jan: Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms;
- 2010 Feb: Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features;
- 2010 Mar-Apr: Downregulation of AKR1B10 gene expression in colorectal cancer;
- 2010 Apr: Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch;
- 2010 Apr: SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells;
- 2010 May: Differentiation therapy exerts antitumor effects on stem-like glioma cells;
- 2010 May: PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation;
- 2010 May: Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells;
- 2010 Jun: The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3beta pathway and beta-catenin stability;
- 2010 Jul: All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma;
- 2010 Jul: Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells;
- 2010 Jul: NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome;
- 2010 Jul-Aug: Expression of retinoic acid receptors in intestinal mucosa and the effect of vitamin A on mucosal immunity;
- 2010 Jul-Sep: All-trans retinoic acid (ATRA) downregulates MMP-9 by modulating its regulatory molecules;
- 2010 Aug: Retinol inhibits aromatase activity and expression in vitro;
- 2010 Nov: RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells;
- 2010 Dec: All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein;
- 2010 Dec: All-trans retinoic acid modulates cancer stem cells of glioblastoma multiforme in an MAPK-dependent manner;
- 2010 Dec: Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth;
- 2011 Mar: All-trans retinoic acid induced the differentiation of human glioma cells;
- 2011 May: Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome;
- 2011 Jul: Action of retinoic acid receptor on EGFR gene transactivation and breast cancer cell proliferation: Interplay with the estrogen receptor;
- 2011 Aug: Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition;
- 2011 Oct: Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression;
- 2012 Feb: Cell growth inhibition and apoptotic effect of the rexinoid 6-OH-11-O-hydroxyphenantrene on human osteosarcoma and mesenchymal stem cells;
- 2012 Apr: Combined effects of melatonin and all-trans retinoic acid and somatostatin on breast cancer cell proliferation and death: molecular basis for the anticancer effect of these molecules;
- 2012 Apr: Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells;
- 2012 May: Retinoid receptors in gastric cancer: expression and influence on prognosis;
- 2012 May: The effects of 5-fluorouracil alone and in combination with 13-cis retinoic acid and vitamin D3 on human oral squamous cell carcinoma lines;
- 2012 Jul: All-trans retinoic acid inhibits tumor growth of human osteosarcoma by activating Smad signaling-induced osteogenic differentiation;
- 2012 Nov: All-trans-retinoic acid inhibits growth of head and neck cancer stem cells by suppression of Wnt/β-catenin pathway;
- 2012 Dec: Inhibition of metastatic lung cancer in C57BL/6 mice by liposome encapsulated all trans retinoic acid (ATRA);
- 2013 Jan: Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo;
- 2013 Feb: Effect of all-trans retinoic acid on the growth of two nasopharyngeal cancer cell lines and its treatment potential in combination with cisplatin;
- 2013 Feb: Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model;
- 2013 Apr: Synergistic effect and mechanism of vitamin A and vitamin D on inducing apoptosis of prostate cancer cells;
- 2013 May: Synergistic effect of retinoic acid and vitamin D analog EB1089-induced apoptosis of hepatocellular cancer cells;
- 2013 Jul: ATRA inhibits the proliferation of DU145 prostate cancer cells through reducing the methylation level of HOXB13 gene;
- 2013 Jul: Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage;
- 2013 Aug: β,β-carotene 15,15'-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells;
- 2013 Aug: Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer;
- 2013 Aug: Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology;
- 2013 Aug: Simultaneous analysis of circulating 25-hydroxy-vitamin D3, 25-hydroxy-vitamin D2, retinol, tocopherols, carotenoids, and oxidized and reduced coenzyme Q10 by high performance liquid chromatography with photo diode-array detection using C18 and C30 columns alone or in combination;
- 2013 Sep: Oncogenic activity of retinoic acid receptor γ is exhibited through activation of the Akt/NF-κB and Wnt/β-catenin pathways in cholangiocarcinoma;
- 2013 Oct: Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists;
- 2013 Nov: Vitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein;
- 2014 Jan: Effects of all-trans retinoic acid, retinol, and beta-carotene on murine macrophage activity;
- 2014 Mar: NADPH-cytochrome P450 reductase is regulated by all-trans retinoic acid and by 1,25-dihydroxyvitamin D3 in human acute myeloid leukemia cells;
- 2014 Apr: All-trans-retinoic acid promotes iodine uptake via up- regulating the sodium iodide symporter in medullary thyroid cancer stem cells;
- 2014 Apr: Growth inhibitory and apoptosis induction effects of all-trans retinoic acid (ATRA) on cervical cancer cell line (HeLa);
- 2014 Apr: Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells;
- 2014 Jun: All trans-retinoic acid (ATRA) induces re-differentiation of early transformed breast epithelial cells;
- 2014 Jun: Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta;
- 2014 Oct: β-Carotene As a Lipophilic Scavenger of Nitric Oxide;
- 2014 Nov: All trans-retinoic acid abrogates the pro-tumorigenic phenotype of prostate cancer tumor-associated macrophages;
- 2014 Nov: Effects of all‑trans retinoic acid on VEGF and HIF‑1α expression in glioma cells under normoxia and hypoxia and its anti‑angiogenic effect in an intracerebral glioma model;
- 2014 Nov: Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3;
- 2014 Dec: Anti-metastatic study of liposome-encapsulated all trans retinoic acid (ATRA) in B16F10 melanoma cells-implanted C57BL/6 mice;
- 2015 Jan: NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes;
- 2015 Mar: All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism;
- 2015 Mar: Comparison of the Effects of 13-cis Retinoic Acid and Melatonin on the Viabilities of SH-SY5Y Neuroblastoma Cell Line;
- 2015 Apr: All-trans retinoic acid downregulates ALDH1-mediated stemness and inhibits tumour formation in ovarian cancer cells;
- 2015 May: MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid;
- 2015 May: Vitamin A Palmitate-β-cyclodextrin inclusion complexes: characterization, protection and emulsification properties;
- 2015 Jun: All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment;
- 2015 Jun: All-trans retinoic acid inhibits migration, invasion and proliferation, and promotes apoptosis in glioma cells in vitro;
- 2015 Jun: Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells;
- 2015 Jun: Myoepithelial and luminal breast cancer cells exhibit different responses to all-trans retinoic acid;
- 2015 Jul: All-trans-retinoic Acid Modulates the Plasticity and Inhibits the Motility of Breast Cancer Cells: ROLE OF NOTCH1 AND TRANSFORMING GROWTH FACTOR (TGFβ);
- 2015 Sep: All-trans retinoic acid mitigates methotrexate-induced liver injury in rats; relevance of retinoic acid signaling pathway;
- 2015 Sep: Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms;
- 2015 Sep: Reduced retinoids and retinoid receptors' expression in pancreatic cancer: A link to patient survival;
- 2015 Nov: All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation;
- 2015 Nov: Retinoid X receptor α enhances human cholangiocarcinoma growth through simultaneous activation of Wnt/β-catenin and nuclear factor-κB pathways;
- 2016 Jan-Mar: The combined effects of all-trans-retinoic acid and docosahexaenoic acid on the induction of apoptosis in human breast cancer MCF-7 cells;
- 2016 Mar: All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy;
- 2016 Apr: Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid;
- 2016 May: Effect of ATRA on the expression of HOXA5 gene in K562 cells and its relationship with cell cycle and apoptosis;
- 2016 Jun: Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer;
- 2016 Aug: RORα and RORγ expression inversely correlates with human melanoma progression;
- 2016 Sep: ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion;
- 2016 Sep: Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-κB;
- 2016 Oct: All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth;
- 2016 Nov: Combined Treatments with a Retinoid Receptor Agonist and Epigenetic Modulators in Human Neuroblastoma Cells;
- 2016 Nov: DNA Methylation of Cellular Retinoic Acid-Binding Proteins in Cervical Cancer;
- 2016 Nov: Retinoic acid receptor β enhanced the anti-cancer stem cells effect of β-carotene by down-regulating expression of delta-like 1 homologue in human neuroblastoma cells;
- 2017 Feb: Anticancer activity of all-trans retinoic acid-loaded liposomes on human thyroid carcinoma cells;
- 2017 Feb: Retinoic acid induces hypersegmentation and enhances cytotoxicity of neutrophils against cancer cells;
- 2017 Mar: All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-α and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer;
- 2017 Mar: Dataset on the changes of neutrophils treated with retinoic acid;
- 2017 Mar: RARα/RXR Synergism Potentiates Retinoid Responsiveness in Cutaneous T Cell Lymphoma Cell Lines;
- 2017 Apr: All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma;
- 2017 May: Topical treatment of All-trans Retinoic Acid inhibits murine melanoma partly by promoting CD8+ T cell immunity;
- 2017 Jun: ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines;
- 2017 Jul: All-trans retinoic acid prevents osteosarcoma metastasis by inhibiting M2 polarization of tumor-associated macrophages;
- 2017 Jul: Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression;
- 2017 Aug: All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis;
- 2017 Nov: All-trans retinoic acid inhibits the proliferation of SGC7901 cells by regulating caveolin-1 localization via the ERK/MAPK signaling pathway;
- 2017 Nov: Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics;
- 2017 Dec: ATRA increases iodine uptake and inhibits the proliferation and invasiveness of human anaplastic thyroid carcinoma SW1736 cells: Involvement of β‑catenin phosphorylation inhibition;
- 2018 May: Tumor Cell-selective Synergism of TRAIL- and ATRA-induced Cytotoxicity in Breast Cancer Cells;
- 2018 Aug: High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling;
- 2018 Aug: The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7 expression;
- 2018 Sep: Differential Potentiation of Retinoic Acid Effects against Human Breast Cancer Cells by Unsaturated Fatty Acids;
- 2018 Sep: Melatonin Can Strengthen the Effect of Retinoic Acid in HL-60 Cells;
- 2018 Oct: The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells;
- 2019 Jan: Anti-tumour effects of all-trans retinoid acid on serous ovarian cancer;
- 2019 Apr: Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells;
- 2019 Apr: S100A3 a partner protein regulating the stability/activity of RARα and PML-RARα in cellular models of breast/lung cancer and acute myeloid leukemia;
- 2019 Apr: Synergistic effect of co-treatment with all-trans retinoic acid and 9-cis retinoic acid on human lung cancer cell line at molecular level;
- 2019 Jul: All-trans retinoic acid therapy induces asymmetric division of glioma stem cells from the U87MG cell line;
- 2019 Sep: All-trans retinoic acid induces anti-tumor effects via STAT3 signaling inhibition in oral squamous cell carcinoma and oral dysplasia;
- 2019 Oct: Self-Assembly Of Retinoid Nanoparticles For Melanoma Therapy;
- 2020 May: All-Trans Retinoic Acid Stimulates Viral Mimicry, Interferon Responses and Antigen Presentation in Breast-Cancer Cells;
- 2020 Sep: Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer;
- 2020 Oct: Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide;
- 2021 Mar: All-trans retinoic acid and protein kinase C α/β1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression;
- 2021 Mar: D-α-Tocopherol-Based Micelles for Successful Encapsulation of Retinoic Acid;
- 2021 Jun: All-Trans Retinoic Acid Fosters the Multifarious U87MG Cell Line as a Model of Glioblastoma;
- 2021 Jul: All-Trans Retinoic Acid Enhances Chemosensitivity to 5-FU by Targeting miR-378c/E2F7 Axis in Colorectal Cancer.
In Vivo (Solo animale)
- 1979 Jun: Augmentation of specific tumor immunity against a syngeneic SV40-induced sarcoma in mice by retinoic acid;
- 1980 Sep: Synergistic effect of chronic prolactin suppression and retinoid treatment in the prophylaxis of N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats;
- 1985 Dec: Anticlastogenic effect of beta-carotene in Chinese hamsters. Time and dose response studies with different mutagens;
- 1986 Jan-Feb: Effect of retinoids on the growth of squamous cell carcinoma of the palate in rats;
- 1986 May: Inhibition of experimental oral carcinogenesis by topical beta carotene;
- 1989 Jan: Inhibition of Moloney murine lymphoma and sarcoma growth in vivo by dietary retinoids;
- 1989 Feb: Regression of experimental cancer by oral administration of combined alpha-tocopherol and beta-carotene;
- 1989 Nov: A highly potent antiangiogenic activity of retinoids;
- 1992 Jan: Beta-carotene as a modulator of chromosomal aberrations induced in mouse bone marrow cells;
- 1992 Sep: Dose-dependent pharmacokinetics of all-trans-retinoic acid;
- 1992 Oct: The effects of retinoic acid on the in vitro and in vivo growth of neuroblastoma cells;
- 1993 Feb: Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells;
- 1993 Nov: Inhibition of tumor cell-induced angiogenesis by retinoids, 1,25-dihydroxyvitamin D3 and their combination;
- 1995 Jul: Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice;
- 1996 Mar: All-trans-retinoic acid inhibits growth of human pancreatic cancer cell lines;
- 1996 Jul: Retinoic acid induces cells cultured from oral squamous cell carcinomas to become anti-angiogenic;
- 1997 Feb: In vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma;
- 1997 Jun: Synergistic antitumor effects of a combination of interferons and retinoic acid on human tumor cells in vitro and in vivo;
- 1998 Sep: Modifying effect of vitamins C, E and beta-carotene against gamma-ray-induced DNA damage in mouse cells;
- 1998 Dec: Retinoic acid and interferon alpha act synergistically as antiangiogenic and antitumor agents against human head and neck squamous cell carcinoma;
- 1999 Mar: Tumor growth inhibition and regression induced by photothermal vascular targeting and angiogenesis inhibitor retinoic acid;
- 2000 Apr: Beta-carotene prolongs survival, decreases lipid peroxidation and enhances glutathione status in transplantable murine lymphoma;
- 2000 May: Differentiation, proliferation and adhesion of human neuroblastoma cells after treatment with retinoic acid;
- 2000 May: Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than by retinoic acid;
- 2000 Sep: Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade;
- 2000 Oct: Regulation of CYP26 (cytochrome P450RAI) mRNA expression and retinoic acid metabolism by retinoids and dietary vitamin A in liver of mice and rats;
- 2001 Aug: Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines;
- 2002 Mar: Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin;
- 2002 Jul: Retinoic acid modulates the ability of macrophages to participate in the induction of the angiogenic phenotype in head and neck squamous cell carcinoma;
- 2002 Sep: Effects of retinoic acid on metastasis and its related proteins in gastric cancer cells in vivo and in vitro;
- 2003 Apr: The synthetic retinoid RO 13-6307 induces neuroblastoma differentiation in vitro and inhibits neuroblastoma tumour growth in vivo;
- 2003 Aug: Combination treatment with 1alpha,25-dihydroxyvitamin D3 and 9-cis-retinoic acid directly inhibits human telomerase reverse transcriptase transcription in prostate cancer cells;
- 2003 Oct: Inhibition of tumor growth by biodegradable microspheres containing all-trans-retinoic acid in a human head-and-neck cancer xenograft;
- 2004 Jul: All-trans retinoic acid-responsive genes identified in the human SH-SY5Y neuroblastoma cell line and their regulated expression in the nervous system of early embryos;
- 2005 Feb: Protective effects of increasing vitamin E and a doses on cisplatin-induced oxidative damage to kidney tissue in rats;
- 2005 Aug: beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation;
- 2006 Feb: Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice;
- 2007 Sep: Alpha-tocopherol, beta-carotene and melatonin administration protects cyclophosphamide-induced oxidative damage to bladder tissue in rats;
- 2007 Nov: Combination of all-trans retinoic acid and taxol regressed glioblastoma T98G xenografts in nude mice;
- 2008 Feb: Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice;
- 2008 Jun: Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma;
- 2009 May: Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion;
- 2009 Sep: Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines;
- 2010 May: Differentiation therapy exerts antitumor effects on stem-like glioma cells;
- 2010 May: Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells;
- 2010 Jul-Aug: Expression of retinoic acid receptors in intestinal mucosa and the effect of vitamin A on mucosal immunity;
- 2011 Aug: Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition;
- 2011 Sep: Inhibition effects of all trans-retinoic acid on the growth and angiogenesis of esophageal squamous cell carcinoma in nude mice;
- 2011 Sep: Physiologic Effect of all Trans Retinoic Acid (Atra) on Vital Organ Damage and Lipid Profile in Benzo (a) Pyrene Induced Lung Metastasis;
- 2011 Oct: Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression;
- 2012 Apr: Chemoprotective effect of all-trans retinoic acid (ATRA) on oxidative stress and lung metastasis induced by benzo(a)pyrene;
- 2012 Jul: All-trans retinoic acid inhibits tumor growth of human osteosarcoma by activating Smad signaling-induced osteogenic differentiation;
- 2012 Nov: All-trans-retinoic acid inhibits growth of head and neck cancer stem cells by suppression of Wnt/β-catenin pathway;
- 2012 Dec: Inhibition of metastatic lung cancer in C57BL/6 mice by liposome encapsulated all trans retinoic acid (ATRA);
- 2013 Jan: Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo;
- 2013 Feb: Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model;
- 2013 May: Synergistic effect of retinoic acid and vitamin D analog EB1089-induced apoptosis of hepatocellular cancer cells;
- 2013 Sep: Oncogenic activity of retinoic acid receptor γ is exhibited through activation of the Akt/NF-κB and Wnt/β-catenin pathways in cholangiocarcinoma;
- 2014 Nov: Effects of all‑trans retinoic acid on VEGF and HIF‑1α expression in glioma cells under normoxia and hypoxia and its anti‑angiogenic effect in an intracerebral glioma model;
- 2014 Dec: Anti-metastatic study of liposome-encapsulated all trans retinoic acid (ATRA) in B16F10 melanoma cells-implanted C57BL/6 mice;
- 2015 Jan: NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes;
- 2015 Apr: All-trans retinoic acid downregulates ALDH1-mediated stemness and inhibits tumour formation in ovarian cancer cells;
- 2015 Jun: Myoepithelial and luminal breast cancer cells exhibit different responses to all-trans retinoic acid;
- 2015 Sep: Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms;
- 2016 Jun: Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer;
- 2016 Oct: All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth;
- 2017 Feb: Retinoic acid induces hypersegmentation and enhances cytotoxicity of neutrophils against cancer cells;
- 2017 Apr: All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma;
- 2017 May: Topical treatment of All-trans Retinoic Acid inhibits murine melanoma partly by promoting CD8+ T cell immunity;
- 2017 Jul: All-trans retinoic acid prevents osteosarcoma metastasis by inhibiting M2 polarization of tumor-associated macrophages;
- 2017 Jul: Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression;
- 2017 Dec: ATRA increases iodine uptake and inhibits the proliferation and invasiveness of human anaplastic thyroid carcinoma SW1736 cells: Involvement of β‑catenin phosphorylation inhibition;
- 2018 Feb: HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis;
- 2019 Jul: Ameliorating effect of lipo-ATRA treatment on the expression of TIG3 and its suppressing effect on PPARγ gene expression in lung cancer animal model;
- 2019 Oct: Self-Assembly Of Retinoid Nanoparticles For Melanoma Therapy;
- 2020 Oct: Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide;
- 2021 Mar: All-trans retinoic acid and protein kinase C α/β1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression.
Review
- 1960 ???: The visual function of the vitamins A;
- 1980 Mar: Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells;
- 1980 Apr: Inhibition of carcinogenesis by retinoids;
- 1981 Oct: Chemoprevention of cancer with retinoids;
- 1988 Aug: Vitamin A derivatives in the prevention and treatment of human cancer;
- 1989 Feb: Antioxidant functions of carotenoids;
- 1989 Sep: Retinoids as potential chemopreventive agents in squamous cell carcinoma of the head and neck;
- 1990 ???: Chemoprevention of Mammary Cancer by Retinoids;
- 1991 Aug: Beta-carotene and the immune response;
- 1992 Feb: Antioxidant effects of carotenoids in vivo and in vitro: an overview;
- 1992 Sep: Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids;
- 1993 Sep: Role of carotenoids in the immune response;
- 1994 ???: Vitamin A, retinoids and breast cancer;
- 1994 Apr: Retinoids in the management of head and neck cancer. An update;
- 1994 Apr: Suppression of squamous cell carcinoma growth and differentiation by retinoids;
- 1995 Feb: Emerging role of beta-carotene and antioxidant nutrients in prevention of oral cancer;
- 1995 Jul: Retinoid chemoprevention of aerodigestive cancer: from basic research to the clinic;
- 1995 Dec: Vitamins E and C, beta-carotene, and other carotenoids as antioxidants;
- 1996 Feb: Retinoid actions and implications for prevention and therapy of oral cancer;
- 1996 May: Beta-carotene, carotenoids, and disease prevention in humans;
- 1996 Dec: Current status of retinoids in chemoprevention of oral squamous cell carcinoma: an overview;
- 1996 Jul: Retinoids in cancer chemoprevention;
- 1996 Aug: Retinoids and apoptosis in cancer therapy;
- 1997 Jan-Feb: All-trans retinoic acid in hematological malignancies, an update;
- 1997 Jul: Carotenoids and retinoids: a review of research, clinical, and public health applications;
- 1997 Sep-Dec: Retinoids and chemoprevention of aerodigestive tract cancers;
- 1998 Oct: The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer;
- 1999 Jan: Leukemia cell differentiation: cellular and molecular interactions of retinoids and vitamin D;
- 1999 Feb: Retinoids in pancreatic cancer;
- 1999 Oct: Role of retinoid receptors in the prevention and treatment of breast cancer;
- 2000 May: Retinoic acid redifferentiation therapy for thyroid cancer;
- 2000 Oct: Retinoids and ovarian cancer;
- 2000 Oct: The retinoids and cancer prevention mechanisms;
- 2000 Nov: Differentiating agents in pediatric malignancies: retinoids in neuroblastoma;
- 2001 May: Retinoid chemoprevention in patients at high risk for skin cancer;
- 2001 Oct: Retinoid therapy of childhood cancer;
- 2001 Dec: Cyclin proteolysis as a retinoid cancer prevention mechanism;
- 2001 Dec: The promise of retinoids to fight against cancer;
- 2002 Jan: Retinoids and their receptors in cancer development and chemoprevention;
- 2002 Sep: The effect of retinoids on premalignant oral lesions: focus on topical therapy;
- 2002 Nov: Retinoid, retinoic acid receptor beta and breast cancer;
- 2002 Dec: Carotenoids in cancer chemoprevention;
- 2002 Dec: Retinoic acid receptors and cancer;
- 2003 Jan: Retinoids and retinoic acid receptor in cancer;
- 2003 Jan- Mar: Clinical applications of retinoids in cancer medicine;
- 2003 Feb: Renaissance of the biologically active vitamin A derivatives: established and novel directed therapies for cancer and chemoprevention;
- 2003 Jun: The role of vitamin D and retinoids in controlling prostate cancer progression;
- 2003 Dec: Antioxidant activity of carotenoids;
- 2004 Apr: Systemic and topical retinoids in the management of skin cancer in organ transplant recipients;
- 2004 May: Retinoids in cancer chemoprevention (Okuno);
- 2004 Jun: How retinoids regulate breast cancer cell proliferation and apoptosis;
- 2004 Dec: Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity;
- 2005 Jan: Redifferentiation Therapy of Thyroid Carcinomas with Retinoic Acid;
- 2005 Jan: Retinoid receptor cross-talk in respiratory epithelium cancer chemoprevention;
- 2005 Mar: Oral retinoids for the prevention of skin cancers in solid organ transplant recipients: a systematic review of randomized controlled trials;
- 2005 Aug: Retinoids as chemoprevention for head and neck cancer: where do we go from here?;
- 2005 Sep: Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer;
- 2005 Dec: Systemic strategies for chemoprevention of skin cancers in transplant recipients;
- 2006 Mar: Clinical trials with retinoids for breast cancer chemoprevention;
- 2006 Jul: Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases;
- 2006 Sep-Oct: Skin cancer chemoprevention with systemic retinoids: an adjunct in the management of selected high-risk patients;
- 2006 Sep-Oct: Treatment of cutaneous T-cell lymphoma with retinoids;
- 2006 Dec: International Union of Pharmacology. LX. Retinoic acid receptors;
- 2007 Jan-Feb: Antioxidants and Other Nutrients Do Not Interfere With Chemotherapy or Radiation Therapy and Can Increase Kill and Increase Survival, Part 1;
- 2007 Mar: Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention;
- 2007 Mar-Apr: Antioxidants and Other Nutrients Do Not Interfere With Chemotherapy or Radiation Therapy and Can Increase Kill and Increase Survival, Part 2;
- 2007 May: The retinoid induced pancreatic cancer redifferentiation-apoptosis sequence and the mitochondria: a suggested obligatory sequence of events;
- 2007 Jul-Aug: Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor;
- 2007 Nov: Diverse actions of retinoid receptors in cancer prevention and treatment;
- 2007 Dec: Emerging role of combination of all-trans retinoic acid and interferon-gamma as chemoimmunotherapy in the management of human glioblastoma;
- 2008 JUn: Systemic retinoids in chemoprevention of non-melanoma skin cancer;
- 2008 Jul: Role of retinoic receptors in lung carcinogenesis;
- 2009 Feb: Anti-angiogenic properties of chemopreventive drugs: fenretinide as a prototype;
- 2009 Jun: Retinoids as critical modulators of immune functions: new therapeutic perspectives for old compounds;
- 2009 Dec: Nutrition and orthomolecular supplementation in lung cancer patients;
- 2010 Jun: All-trans retinoic acid (ATRA) in prevention and cancer therapy (Article in Polish);
- 2010 Oct: Retinoid pathway and cancer therapeutics;
- 2011 Feb: Retinoids for chemoprophylaxis of nonmelanoma skin cancer;
- 2011 Feb: Retinoids regulate stem cell differentiation;
- 2011 Feb: Retinoids, retinoic acid receptors, and cancer;
- 2011 Jun: All trans retinoic acid and cancer;
- 2012 Feb: EMBO Retinoids 2011: mechanisms, biology and pathology of signaling by retinoic acid and retinoic acid receptors;
- 2012 Feb: The use of retinoids in ovarian cancer: a review of the literature;
- 2012 Feb: Vitamin A and risk of cervical cancer: a meta-analysis;
- 2012 Mar: Cancer chemoprevention by carotenoids;
- 2012 May: Solid tumor differentiation therapy - is it possible?;
- 2012 Aug: Acyclic retinoid in chemoprevention of hepatocellular carcinoma: Targeting phosphorylated retinoid X receptor-α for prevention of liver carcinogenesis;
- 2012 Aug: Retinoids and carotenoids in general medicine;
- 2012 Oct: Retinoids: novel immunomodulators and tumour-suppressive agents?;
- 2012 Nov: A global clinical view on vitamin A and carotenoids;
- 2012 Dec: Antioxidants and its role in Oral Cancer- A Review;
- 2013 Mar-Apr: Retinoids: Potent regulators of metabolism;
- 2013 Apr: Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment;
- 2013 Jun: Retinoids in the chemoprevention of non-melanoma skin cancers: why, when and how;
- 2013 Jul: Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids;
- 2013 Aug: Retinoids and nuclear retinoid receptors in white and brown adipose tissues: physiopathologic aspects;
- 2013 Sep: Absorption of vitamin A and carotenoids by the enterocyte: focus on transport proteins;
- 2014 Jan: Functions, therapeutic applications, and synthesis of retinoids and carotenoids;
- 2014 Jan: Potential role of carotenoids as antioxidants in human health and disease;
- 2014 Jan: Retinoic acid signaling pathways in development and diseases;
- 2014 Jan: Retinoids and their biological effects against cancer;
- 2014 Mar: Tumor microenvironment: the promising target for tumor therapy;
- 2014 Jun: The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes;
- 2014 Jul: A role for acyclic retinoid in the chemoprevention of hepatocellular carcinoma: therapeutic strategy targeting phosphorylated retinoid X receptor-α;
- 2014 Jul: Retinoids and breast cancer: from basic studies to the clinic and back again;
- 2014 Aug: Vitamin A, cancer treatment and prevention: the new role of cellular retinol binding proteins;
- 2014 Nov: Retinoic acid and cancer treatment;
- 2014 Dec: Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies;
- 2015 Mar: Vitamin A, cancer treatment and prevention: the new role of cellular retinol binding proteins;
- 2015 Apr: Carotenoids as natural antioxidants;
- 2015 Apr: Dormancy programs as emerging antimetastasis therapeutic alternatives;
- 2015 Aug: Alterations in Retinoic Acid Receptors in Non-Small Cell Lung Cancer and Their Clinical Implications;
- 2015 Aug: Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6;
- 2015 Oct: Role of retinoids in the prevention and treatment of colorectal cancer;
- 2016 Feb: Retinoids in the pancreas;
- 2016 Mar: Role of nuclear receptors in breast cancer stem cells;
- 2017 Oct: Redifferentiation of Radioiodine Refractory Differentiated Thyroid Cancer for Reapplication of I-131 Therapy;
- 2018 May: Antioxidants in Oral Diseases and Future Prospects and their Application in Dentistry;
- 2018 May: Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis.
- 2018 Aug: Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases;
- 2018 Aug: Preventive measures in oral cancer: An overview;
- 2018 Oct: Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review;
- 2018 Oct: The success and the challenge of all-trans retinoic acid in the treatment of cancer;
- 2018 Dec: Immune cells in the tumour: new routes of retinoids for chemoprevention and chemotherapeutics;
- 2019 Aug: Modulation of all-trans retinoic acid-induced MiRNA expression in neoplastic cell lines: a systematic review;
- 2019 Oct: Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type.
Editoriali - Lettere al' editore
- 1985 Jan-Feb: Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma;
- 1988 Apr: The modifying effect of beta-carotene on radiation and chemotherapy induced oral mucositis;
- 1992 Aug: beta-Carotene and alpha-tocopherol are synergistic antioxidants;
- 1992 Sep: Retinoids and cancer therapy;
- 1994 Nov: Combination of isotretinoin and calcitriol for precancerous and cancerous skin lesions;
- 1997 Jan: Ascorbic acid and beta-carotene as modulators of oxidative damage;
- 1997 Jan: Carotenoids Enhance Vitamin E Antioxidant Efficiency;
- 1999 Jun: Aberrant expression of retinoid receptors and lung carcinogenesis;
- 2000 Feb: Vitamin nutrition and gastroesophageal cancer;
- 2000 Mar: Aberrant retinoid signaling and breast cancer: the view from outside the nucleus;
- 2000 Aug: Aerosolized delivery and lung cancer prevention: pre-clinical models show promise;
- 2001 Jul: The Reaction Mechanism of the Enzyme-Catalyzed Central Cleavage of beta-Carotene to Retinal;
- 2003 Feb: Predicting success in cancer prevention trials;
- 2004 May: Dramatic efficacy of oral aromatic retinoid in long-standing hypertrophic lupus erythematosus;
- 2006 Feb: Antioxidants in cancer therapy;
- 2012 Sep: Retinoids and breast cancer: new clues to increase their activity and selectivity;
- 2015 Dec: Combination therapies improve the anticancer activities of retinoids in neuroblastoma;
- 2018 Feb: Carotenoids-Antioxidant Properties;
Meta-Analysis
- 2011 Oct: Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression;
- 2012 Feb: Vitamin A and risk of cervical cancer: a meta-analysis;
- 2014 Dec: Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies;
- 2016 Apr: Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium;
- 2018 Mar: Clinical Significance of Retinoic Acid Receptor Beta Promoter Methylation in Prostate Cancer: A Meta-Analysis.
In Vivo (Su uomo: Case Reports/Series, Clinical Trials, Studi comparativi, Prove controllate, randomizzate e Studi retrospettivi)
- 1987 Feb: Long-term retinoid therapy is needed for maintenance of cancer chemopreventive effect;
- 1988 ???: Lung cancer chemoprevention with retinol palmitate. Preliminary data from a randomized trial on stage Ia non small-cell lung cancer;
- 1988 Apr: The modifying effect of beta-carotene on radiation and chemotherapy induced oral mucositis;
- 1988 May: Response of oral leukoplakias to the administration of vitamin A;
- 1988 Aug: Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta-carotene and with beta-carotene plus vitamin A;
- 1990 Feb: Plasma vitamin E and beta-carotene concentrations during radiochemotherapy preceding bone marrow transplantation;
- 1990 Sep: Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck;
- 1990 Sep: Relationships of vitamins A and E and beta-carotene serum levels to head and neck cancer patients with and without second primary tumors;
- 1990 Dec: Interferon alpha and etretinate combination treatment of cutaneous T-cell lymphoma;
- 1991 Mar: The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans;
- 1991 Nov: The treatment of 45 patients with cutaneous T-cell lymphoma with low doses of interferon-alpha 2a and etretinate;
- 1993 Jan: Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis;
- 1994 Apr: Retinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis;
- 1996 Feb: Redifferentiation therapy of differentiated thyroid carcinoma with retinoic acid: basics and first clinical results;
- 1996 Oct: Resolution of recurrent malignant ganglioglioma after treatment with cis-retinoic acid;
- 1996 Nov-Dec: Long-term follow-up of larynx leukoplakia under treatment with retinyl palmitate;
- 1997 Apr: All-trans retinoic acid and interferon-alpha-2a in patients with metastatic or recurrent carcinoma of the uterine cervix: clinical and pharmacokinetic studies. New York Gynecologic Oncology Group;
- 1997 Jul: Chemoprevention of oral leukoplakia with vitamin A and beta carotene: an assessment;
- 1997 Sep: All-trans retinoic acid in relapsing malignant gliomas: clinical and radiological stabilization associated with the appearance of intratumoral calcifications;
- 1997 Nov: Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group;
- 1997 Nov: Expression of retinoic acid receptor-beta 2 mRNA in normal cervical epithelium and cervical squamous cell carcinoma;
- 1997 Nov: Intake of selected micronutrients and risk of colorectal cancer;
- 1997 Nov-Dec: The effects of 13-cis retinoic acid and interferon-alpha in chronic myelogenous leukemia cells in vivo in patients;
- 1997 Dec: An Eastern Cooperative Oncology Group phase I trial of all-trans-retinoic acid and interferon-alpha: E2Y92;
- 1997 Dec: The use of tretinoin as oral mucositis prophylaxis in bone marrow transplantation patients: a preliminary study;
- 1998 Mar: Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial;
- 1998 Jun: Redifferentiation therapy with retinoids: therapeutic option for advanced follicular and papillary thyroid carcinoma;
- 1998 Sep: Redifferentiation therapy with retinoic acid in follicular thyroid cancer;
- 1998 Oct: Beta-carotene with vitamins E and C offers synergistic cell protection against NOx;
- 1998 Dec: Beta-carotene concentration in buccal mucosal cells with and without dysplastic oral leukoplakia after long-term beta-carotene supplementation in male smokers;
- 1999 Feb: High dose etretinate and interferon-alpha--a phase I study in squamous cell carcinomas and transitional cell carcinomas;
- 1999 Oct: Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group;
- 2000 Feb: Vitamin nutrition and gastroesophageal cancer;
- 2000 Mar: beta-Carotene and selenium supplementation enhances immune response in aged humans;
- 2000 Mar: Phase I trial of all-trans retinoic acid in patients with treated head and neck squamous carcinoma;
- 2001 Apr: Cyclophosphamide plus somatostatin, bromocriptin, retinoids, melatonin and ACTH in the treatment of low-grade non-Hodgkin's lymphomas at advanced stage: results of a phase II trial;
- 2001 Jun: Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid;
- 2001 Jun: Combined interferon-alfa, 13-cis-retinoic acid, and alpha-tocopherol in locally advanced head and neck squamous cell carcinoma: novel bioadjuvant phase II trial;
- 2001 Jun: Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor;
- 2002 May: beta-Carotene and alpha-tocopherol concentration and antioxidant status in buccal mucosal cells and plasma after oral supplementation;
- 2002 Jun: Clinical impact of retinoids in redifferentiation therapy of advanced thyroid cancer: final results of a pilot study;
- 2003 Feb: Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: results from a randomized placebo-controlled trial;
- 2003 Mar: Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer;
- 2003 Jun: Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study;
- 2004 May: Dramatic efficacy of oral aromatic retinoid in long-standing hypertrophic lupus erythematosus;
- 2004 Jun: Low antioxidant vitamin intakes are associated with increases in adverse effects of chemotherapy in children with acute lymphoblastic leukemia;
- 2005 Apr: Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ transplant recipients: a 16-year retrospective study;
- 2006 Feb: Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status;
- 2006 Nov-Dec: Relapse of high-grade non-Hodgkin's lymphoma after autologous stem cell transplantation: a case successfully treated with cyclophosphamide plus somatostatin, bromocriptine, melatonin, retinoids, and ACTH;
- 2007 Jan-Feb: Low-grade non-Hodgkin lymphoma at advanced stage: a case successfully treated with cyclophosphamide plus somatostatin, bromocriptine, retinoids, and melatonin;
- 2007 Feb: Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in chemotherapy-pretreated patients with advanced lung adenocarcinoma and low performance status;
- 2007 Nov: Proliferative changes in the bronchial epithelium of former smokers treated with retinoids;
- 2007 Nov-Dec: Serum alpha-tocopherol, retinol and neopterin during paclitaxel/carboplatin chemotherapy;
- 2008 Dec: Complete objective response to biological therapy of plurifocal breast carcinoma;
- 2009 Feb: Randomized trial of 13-cis retinoic acid compared with retinyl palmitate with or without beta-carotene in oral premalignancy;
- 2009 Mar: Effectiveness of retinoic acid treatment for redifferentiation of thyroid cancer in relation to recovery of radioiodine uptake;
- 2009 Jun: Chronic lymphocytic leukemia: long-lasting remission with combination of cyclophosphamide, somatostatin, bromocriptine, retinoids, melatonin, and ACTH;
- 2009 Sep: Complete objective response of oesophageal squamocellular carcinoma to biological treatment;
- 2009 Oct: Complete objective response of neuroblastoma to biological treatment;
- 2010 Jul: Randomized phase II trial of All-trans-retinoic acid with chemotherapy based on paclitaxel and cisplatin as first-line treatment in patients with advanced non-small-cell lung cancer;
- 2010 Sep: Serum retinol, alpha-tocopherol and systemic inflammatory response in metastatic colorectal carcinoma patients treated with combination chemotherapy and cetuximab;
- 2011 Jan: Follow-up of patients treated with retinoic acid for the control of radioiodine non-responsive advanced thyroid carcinoma;
- 2011 Jul: Retinoic acid therapy in patients with radioiodine negative differentiated thyroid cancer and clinical or biochemical evidence of disease: An initial experience;
- 2011 Sep: The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 122 cases of breast cancer;
- 2011 Oct: Combined therapy with 131I and retinoic acid in Korean patients with radioiodine-refractory papillary thyroid cancer;
- 2012 May: Retinoid receptors in gastric cancer: expression and influence on prognosis;
- 2012 May: The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck;
- 2012 Jul: Systemic retinoid therapy for chemoprevention of nonmelanoma skin cancer in a patient treated with vemurafenib;
- 2012 Dec: The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 55 cases of lymphomas;
- 2013 Nov: The Di Bella Method (DBM) in the treatment of prostate cancer: a preliminary retrospective study of 16 patients and a review of the literature;
- 2013 Dec: Evaluation of the safety and efficacy of the first-line treatment with somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide in 20 cases of breast cancer: a preliminary report;
- 2015 May: Recurrent Glioblastoma Multiforme (grade IV – WHO 2007): a case of complete objective response achieved by means of the concomitant administration of Somatostatin and Octreotide – Retinoids – Vitamin E – Vitamin D3 – Vitamin C – Melatonin – D2 R agonists (Di Bella Method – DBM) associated with Temozolomide;
- 2015 Oct: 100% Complete response rate in patients with cutaneous metastatic melanoma treated with intralesional interleukin (IL)-2, imiquimod, and topical retinoid combination therapy: results of a case series;
- 2016 Jan: Congenital fibrosarcoma in complete remission with Somatostatin, Bromocriptine, Retinoids, Vitamin D3, Vitamin E, Vitamin C, Melatonin, Calcium, Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow Up. Case Report;
- 2016 Feb: Malignant Transformation of Teratoma to Adenocarcinoma With Complete Remission With All-Trans Retinoic Acid-Based Treatment and Surgery;
- 2016 Oct: Pharmacokinetics and pharmacogenetics of 13-cis retinoic acid in Indian high-risk neuroblastoma patients;
- 2017 Dec: Complete objective response, stable for 5 years, with the Di Bella Method, of multiple-metastatic carcinoma of the breast;
- 2018 Mar: The Synergism of Somatostatin, Melatonin, Vitamins Prolactin and Estrogen Inhibitors Increased Survival, Objective Response and Performance Status In 297 Cases of Breast Cancer;
- 2018 Sep: Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients;
- 2020 Mar: Efficacy of oral retinoids for keratoacanthoma centrifugum marginatum.